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Circadian regulation of metabolic homeostasis: causes and consequences

Authors McGinnis G, Young M

Received 2 February 2016

Accepted for publication 30 March 2016

Published 27 May 2016 Volume 2016:8 Pages 163—180

DOI https://doi.org/10.2147/NSS.S78946

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Steven A Shea


Graham R McGinnis, Martin E Young

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

Abstract: Robust circadian rhythms in metabolic processes have been described in both humans and animal models, at the whole body, individual organ, and even cellular level. ­Classically, these time-of-day-dependent rhythms have been considered secondary to fluctuations in energy/nutrient supply/demand associated with feeding/fasting and wake/sleep cycles. Renewed interest in this field has been fueled by studies revealing that these rhythms are driven, at least in part, by intrinsic mechanisms and that disruption of metabolic synchrony invariably increases the risk of cardiometabolic disease. The objectives of this paper are to provide a comprehensive review regarding rhythms in glucose, lipid, and protein/amino acid metabolism, the relative influence of extrinsic (eg, neurohumoral factors) versus intrinsic (eg, cell autonomous circadian clocks) mediators, the physiologic roles of these rhythms in terms of daily fluctuations in nutrient availability and activity status, as well as the pathologic consequences of dyssynchrony.

Keywords: circadian rhythm, circadian clocks, metabolic homeostasis, neurohumoral factors, dyssynchrony, time-of-day-dependent rhythms

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