Back to Archived Journals » Journal of Neurorestoratology » Volume 5

Chromaffin cell transplantation for neuropathic pain after spinal cord injury: a report of two cases

Authors Chen L, Xi HT, Xiao J, Zhang F, Chen D, Huang HY

Received 19 August 2016

Accepted for publication 10 October 2016

Published 13 February 2017 Volume 2017:5 Pages 47—50

DOI https://doi.org/10.2147/JN.S120173

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Hari Shanker Sharma


Lin Chen,1,2 Haitao Xi,1 Juan Xiao,1 Feng Zhang,1 Di Chen,1 Hongyun Huang,1,3

1Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, 2Department of Neurosurgery, Tsinghua University Yuquan Hospital, 3Neurorestoratology Institute, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China

Abstract: Neuropathic pain (NP), a common secondary complication following spinal cord injury (SCI), presenting at or below the level of injury is largely refractory to current pharmacological, physical, and surgical treatments. Previous studies have demonstrated the promising value of cell therapy including adrenal chromaffin cells that have the capacity to act as mini-pumps that release amines and peptides for alleviating chronic pain. The paper presents the cases of two gentlemen suffering from severe central NP after thoracic SCI. Six months after chromaffin cell intrathecal injection, their pain relieved significantly. The results demonstrated the preliminary therapeutic efficacy of chromaffin cell transplants in people with NP, and support further research of this treatment strategy for the management of intractable chronic pain due to SCI.

Keywords: chromaffin cell, cell transplantation, neuropathic pain, spinal cord injury

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]