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Chikungunya virus outbreak expansion and microevolutionary events affecting epidemiology and epidemic potential

Authors Powers A

Received 4 December 2014

Accepted for publication 3 February 2015

Published 30 March 2015 Volume 2015:6 Pages 11—19

DOI https://doi.org/10.2147/RRTM.S53698

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Unnasch


Ann M Powers

Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA

Abstract:
Chikungunya virus (CHIKV) is a mosquito-borne virus that is associated with severe and prolonged arthralgia. Starting in 2004, CHIKV reemerged in a series of outbreaks along the east coast of Africa and on several islands of the Indian Ocean. Over the subsequent 10 years, the virus spread throughout the globe and caused over three million cases. Molecular characterization of the genomes over time revealed changes that were associated with changes in epidemiology and transmission patterns. Monitoring and exploitation of these changes may lead to better understanding of viral movement and potential options for prevention and control.

Keywords: chikungunya, alphaviral evolution, molecular epidemiology, transmission, outbreaks

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