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Chemotherapy-induced anemia: etiology, pathophysiology, and implications for contemporary practice

Authors Bryer E, Henry D

Received 14 September 2018

Accepted for publication 23 October 2018

Published 16 November 2018 Volume 2018:6 Pages 21—31

DOI https://doi.org/10.2147/IJCTM.S187569

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Cees Th. Smit Sibinga


Emily Bryer, David Henry

Internal Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA

Abstract: Chemotherapy-induced anemia (CIA) is a multifaceted entity influenced by a variety of patient- and treatment-specific factors. Some sources of variation within CIA include chemotherapeutic agent as well as dose and administration schedule, type and stage of malignancy, baseline pretreatment hemoglobin, target hemoglobin, timing of intervention (red blood cell transfusion, iron, erythropoietin stimulating agent), nutritional status, renal function, age, and gender. The diversity of patient presentation and symptomatology within the broader spectrum of CIA contributes to the challenge of establishing universal criteria to govern optimal management therapies. This manuscript will review the development and evolution of CIA with an emphasis on assorted therapeutic interventions.

Keywords: chemotherapy-induced anemia, red blood cell transfusion, erythrocyte stimulating agent, iron

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