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Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility

Authors Kim MH, Park WH

Received 15 February 2016

Accepted for publication 14 April 2016

Published 23 June 2016 Volume 2016:11 Pages 2967—2978

DOI https://doi.org/10.2147/IJN.S106467

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Min Hee Kim, Won Ho Park

Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, Korea

Abstract: In this study, the synthesis of silk fibroin (SF) hydrogel via chemical cross-linking reactions of SF due to gamma-ray (γ-ray) irradiation was investigated, as were the resultant hydrogel’s properties. Two different hydrogels were investigated: physically cross-linked SF hydrogel and chemically cross-linked SF hydrogel irradiated at different doses of γ-rays. The effects of the irradiation dose and SF concentration on the hydrogelation of SF were examined. The chemically cross-linked SF hydrogel was compared with the physically cross-linked one with regard to secondary structure and gel strength. Furthermore, the swelling behavior, crystallinity, and biodegradation of the SF hydrogels were characterized. To assay cell proliferation, the cell viability of human mesenchymal stem cells on the lyophilized SF hydrogel scaffolds was evaluated, and no significant cytotoxicity against human mesenchymal stem cells was observed.

Keywords: silk fibroin, hydrogels, biodegradation rate, gamma irradiation, cross-linking

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