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Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine

Authors Chung WJ, Lee DY, Yoo SY

Received 7 September 2014

Accepted for publication 25 October 2014

Published 12 December 2014 Volume 2014:9(1) Pages 5825—5836

DOI https://doi.org/10.2147/IJN.S73883

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Thomas J Webster

Woo-Jae Chung,1 Doe-Young Lee,1 So Young Yoo2,3

1College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea; 2BIO-IT Foundry Technology Institute, Pusan National University, Busan, Republic of Korea; 3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea


Abstract: M13 bacteriophage (phage) has emerged as an attractive bionanomaterial owing to its genetically tunable surface chemistry and its potential to self-assemble into hierarchical structures. Furthermore, because of its unique nanoscopic structure, phage has been proposed as a model system in soft condensed physics and as a biomimetic building block for structured functional materials. Genetic engineering of phage provides great opportunities to develop novel nanomaterials with functional surface peptide motifs; however, this biological approach is generally limited to peptides containing the 20 natural amino acids. To extend the scope of phage applications, strategies involving chemical modification have been employed to incorporate a wider range of functional groups, including synthetic chemical compounds. In this review, we introduce the design of chemoselective phage functionalization and discuss how such a strategy is combined with genetic engineering for a variety of medical applications, as reported in recent literature.

Keywords: M13 bacteriophage, chemoselective modification, functionalization, biomimetic structure, bionanomaterial

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