Back to Journals » Open Access Journal of Clinical Trials » Volume 1 » Default

Challenges with engaging participants in behavioral intervention research trials

Authors Olem D, Sharp KM, Johnson M

Published 18 November 2009 Volume 2009:1(Default) Pages 17—21


Review by Single-blind

Peer reviewer comments 4

David Olem, Kelly M Sharp, Mallory O Johnson

Department of Medicine, University of California, San Francisco, CA, USA

Abstract: In clinical trials research, nonadherence to an investigational health promotion intervention poses threats to internal validity, thus raising concern over the trial outcomes and interpretation of results. Successfully helping participants to engage in and complete a multisession intervention can be particularly challenging. This task can become more complicated when working with participants who are dealing with chronic health conditions and are from diverse cultural, socio-economic, and marginalized backgrounds who may have competing needs, beliefs, and priorities that conflict with the needs of the trial protocols. This paper identifies some of the challenges to helping individuals participate in the sessions of a behavioral intervention and shares a set of strategies developed by a clinical research team to engage with participants and minimize barriers to completing the intervention.

Keywords: clinical trials, behavioral interventions, retention, internal validity

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Other article by this author:

Preliminary support for the construct of health care empowerment in the context of treatment for human immunodeficiency virus

Johnson MO, Sevelius JM, Dilworth SE, Saberi P, Neilands TB

Patient Preference and Adherence 2012, 6:395-404

Published Date: 11 May 2012

Readers of this article also read:

Detection of hepatitis C virus core protein in serum by atomic force microscopy combined with mass spectrometry

Ivanov YD, Kaysheva AL, Frantsuzov PA, Pleshakova TO, Krohin NV, Izotov AA, Shumov ID, Uchaikin VF, Konev VA, Ziborov VS, Archakov AI

International Journal of Nanomedicine 2015, 10:1597-1608

Published Date: 25 February 2015

Aqueous misdirection syndrome: an interesting case presentation

Moinul P, Hutnik CML

Clinical Ophthalmology 2015, 9:183-186

Published Date: 29 January 2015

Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment

Madani SY, Shabani F, Dwek MV, Seifalian AM

International Journal of Nanomedicine 2013, 8:941-950

Published Date: 3 March 2013

Efficacy of various antioxidants in the protection of the retinal pigment epithelium from oxidative stress

Kagan DB, Liu H, Hutnik CML

Clinical Ophthalmology 2012, 6:1471-1476

Published Date: 7 September 2012

Critical appraisal of cardiac implantable electronic devices: complications and management

Padeletti L, Mascioli G, Paoletti Perini A, Grifoni G, Perrotta L, Marchese P, Bontempi L, Curnis A

Medical Devices: Evidence and Research 2011, 4:157-167

Published Date: 9 September 2011

Atypical eating disorders: a review

Garcia FD, Délavenne H, Déchelotte P

Nutrition and Dietary Supplements 2011, 3:67-75

Published Date: 12 April 2011

Hepatic progenitors for liver disease: current position

Alice Conigliaro, David A Brenner, Tatiana Kisseleva

Stem Cells and Cloning: Advances and Applications 2010, 3:39-47

Published Date: 25 February 2010