Back to Journals » Neuropsychiatric Disease and Treatment » Volume 16

Cerebral Salt Wasting in Traumatic Brain Injury Is Associated with Increased Morbidity and Mortality

Authors Chendrasekhar A, Chow PT, Cohen D, Akella K, Vadali V, Bapatla A, Patwari J, Rubinshteyn V, Harris L

Received 4 October 2019

Accepted for publication 11 February 2020

Published 25 March 2020 Volume 2020:16 Pages 801—806


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Akella Chendrasekhar,1,2 Priscilla T Chow,1,2 Douglas Cohen,1 Krishna Akella,1,2 Vinay Vadali,1,2 Alok Bapatla,1,2 Jakey Patwari,1 Vladimir Rubinshteyn,1 Loren Harris1,2

1Department of Surgery, Richmond University Medical Center, Staten Island, NY, USA; 2Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA

Correspondence: Akella Chendrasekhar Email

Introduction: In the setting of cerebral injury, cerebral salt wasting (CSW) is a potential cause of hyponatremia, which contributes to adverse effects and mortality.
Objective: The primary objective of this study was to evaluate the clinical outcomes of severe traumatic brain injury (TBI) patients complicated by CSW.
Methods: A retrospective data analysis was performed on data collected from patients with TBI with an abbreviated injury scale (AIS) greater than 3. Data was divided into 2 groups of patients with CSW and those without. The primary endpoint was incidence of adverse effects of CSW in regard to injury severity score (ISS), hospital length of stay (HLOS), ventilator days, ICU length of stay (ICU LOS) and survival to discharge. Data was analyzed using a one-way analysis of variance (ANOVA).
Results: A total of  310 consecutive patients with severe head injury (anatomic injury score 3 or greater) were evaluated over a 3-year period. A total of 125 of the 310 patients (40%) were diagnosed with cerebral salt wasting as defined by hyponatremia with appropriate urinary output and salt replacement. Patients with CSW had poorer outcomes in regard to ISS (21.8 vs 14.2, p< 0.0001), HLOS (14.1 vs 3.5, p< 0.0001), ventilator days (5.0 vs 0.45, p< 0.0001), ICU LOS (8.5 vs 1.6, p< 0.0001), and survival to discharge (88% vs 99%, p< 0.0001).
Discussion: Common adverse effects of CSW were noted in this study. Patients with TBI have a predilection towards development of CSW and consequently have poorer outcomes including increased morbidity and mortality. Data is sparse on the duration of CSW and degree of hyponatremia over time. Larger, comparative studies need to be performed to investigate the hyponatremic patient population and the clinical outcomes of those who present with CSW.

Keywords: hyponatremia, hypovolemia, Natriuresis, traumatic brain injury, neurosurgery

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]