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Celecoxib suppresses cutaneous squamous-cell carcinoma cell migration via inhibition of SDF1-induced endocytosis of CXCR4

Authors Gong T, Yu Y, Yang B, Lin M, Huang JW, Cheng B, Ji C

Received 17 July 2018

Accepted for publication 15 October 2018

Published 12 November 2018 Volume 2018:11 Pages 8063—8071

DOI https://doi.org/10.2147/OTT.S180472

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Geoffrey Pietersz


Ting Gong,1,* Yan Yu,2,* Bo Yang,3 Min Lin,4 Jin-Wen Huang,4 Bo Cheng,4 Chao Ji4

1Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China; 2Department of Dermatology, First Hospital of Jilin University, Changchun, Jilin 130021, China; 3Department of Dermatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 4Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China

*These authors contributed equally to this work

Background: Cutaneous squamous cell carcinoma (CSCC), the main type of non-melanoma skin cancer (NMSC), contributes to 20-30% of the overall number of NMSC cases. Some CSCCs are observed to have metastatic potential induced by solar ultra violet (UV) radiation. Celecoxib, a nonsteroidal anti-inflammatory drug, has been largely associated with prevention of many cancer types. However, the relationship between celecoxib and CSCC cell migration has yet to be determined.
Methods: To determine the association between celecoxib and CSCC, we performed a series of studies in human samples and in vitro models to assess the influence of celecoxib in CSCC cell migration.
Results: In the present study, we found that celecoxib suppresses CSCC cell migration via inhibition of SDF1-induced endocytosis of CXCR4. In addition, ERK/AKT signaling pathways were found to play a key role in this biological process.
Conclusion: Our study provides promising evidence that celecoxib could serve as a potential preventative agent for the metastasis of CSCC cells.

Keywords:
celecoxib, SDF1, cell migration, CXCR4, ERK–Akt pathway

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