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Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab

Authors Greenwood G

Received 17 June 2015

Accepted for publication 20 August 2015

Published 13 October 2015 Volume 2015:8 Pages 235—239

DOI https://doi.org/10.2147/IMCRJ.S90640

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Ronald Prineas


Gregory T Greenwood

Nephrology Associates, PLLC, Winston-Salem, NC, USA

Abstract: Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by chronic, uncontrolled activation of the alternative complement pathway, leading to thrombotic microangiopathy. Renal impairment and progression to end-stage renal disease are common in untreated patients with aHUS, and extrarenal manifestations are being increasingly characterized in the literature. Ocular involvement remains rare in aHUS. This report describes a patient with aHUS with bilateral central retinal artery and vein occlusion, vitreous hemorrhage, and blindness in addition to renal impairment. The patient’s hematologic and renal parameters and ocular manifestation improved following initiation of eculizumab therapy.

Keywords: acute kidney injury, complement, dialysis, plasma exchange, thrombotic microangiopathy

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