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Case Report: Metachronous Quadruple Cancers Including Breast Cancer and Triple Genital Cancer

Authors Bai J, Xie Z, Sun L

Received 2 September 2020

Accepted for publication 19 November 2020

Published 16 December 2020 Volume 2020:13 Pages 1575—1580

DOI https://doi.org/10.2147/IJGM.S278219

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Jing Bai,1,* Zhaoguang Xie,1,* Li Sun2

1Department of Maternity, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan 250001, People’s Republic of China; 2Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao 266042, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Li Sun Tel +86-18953109686
Email sunli766@163.com

Abstract: Most multiple primary cancers(MPCs) are double primaries, while quadruple cancer is rare, especially breast cancer and triple genital cancer. Our work is the first report about ametachronous quadruple cancer in the reproductive system, including breast, ovary, fallopian tube and cervix. A54-year-old woman, who underwent modified radical mastectomy and right breast tumor resection 3 years ago, presented with abnormal vaginal discharge for 2 months, and she was subsequently diagnosed with stage IIA2 cervical squamous cell carcinoma. She then underwent radiotherapy and chemotherapy, as well as radical hysterectomy, bilateral salpingo-oophorectomy and bilateral pelvic lymphadenectomy. Postoperative pathological findings revealed that the patient had cervical, ovarian and tubal triple cancers with different histopathology for all lesions, also different from breast cancer, implying that these tumors had separate etiology and were not metastatic tumors. Our work might provide aseries of diagnostic, etiological and therapeutic strategies for MPC patients.

Keywords: quadruple cancer, multiple primary carcinoma, metachronous cancer, genital cancer

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