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Cardiac allograft immune activation: current perspectives

Authors Chang D, Kobashigawa JA

Received 12 July 2014

Accepted for publication 26 August 2014

Published 18 December 2014 Volume 2015:7 Pages 13—22

DOI https://doi.org/10.2147/TRRM.S71055

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Qing Yi


Video abstract presented by David Chang and Jon Kobashigawa.

Views: 162

David Chang, Jon Kobashigawa

Cedars-Sinai Heart Institute, Los Angeles, CA, USA

Abstract: Heart transplant remains the most durable option for end-stage heart disease. Cardiac allograft immune activation and heart transplant rejection remain among the main complications limiting graft and recipient survival. Mediators of the immune system can cause different forms of rejection post-heart transplant. Types of heart transplant rejection include hyperacute rejection, cellular rejection, antibody-mediated rejection, and chronic rejection. In this review, we will summarize the innate and adaptive immune responses which influence the post-heart transplant recipient. Different forms of rejection and their clinical presentation, detection, and immune monitoring will be discussed. Treatment of heart transplant rejection will be examined. We will discuss potential treatment strategies for preventing rejection post-transplant in immunologically high-risk patients with antibody sensitization.

Keywords: heart transplant, innate immunity, adaptive immunity, rejection, immunosuppression


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