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Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Authors Tonelli FMP, Santos AK, Gomes KN, Lorençon E, Guatimosim S, Ladeira LO, Resende R

Received 5 May 2012

Accepted for publication 14 June 2012

Published 14 August 2012 Volume 2012:7 Pages 4511—4529

DOI https://doi.org/10.2147/IJN.S33612

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Fernanda MP Tonelli,1 Anderson K Santos,1 Katia N Gomes,2 Eudes Lorençon,2 Silvia Guatimosim,3 Luiz O Ladeira,2 Rodrigo R Resende1

1Cell Signaling and Nanobiotechnology Laboratory, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil; 2Nanomaterials Laboratory, Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil; 3Intracellular Cardiomiocyte Signaling Laboratory, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil

Abstract: In recent years, significant progress has been made in organ transplantation, surgical reconstruction, and the use of artificial prostheses to treat the loss or failure of an organ or bone tissue. In recent years, considerable attention has been given to carbon nanotubes and collagen composite materials and their applications in the field of tissue engineering due to their minimal foreign-body reactions, an intrinsic antibacterial nature, biocompatibility, biodegradability, and the ability to be molded into various geometries and forms such as porous structures, suitable for cell ingrowth, proliferation, and differentiation. Recently, grafted collagen and some other natural and synthetic polymers with carbon nanotubes have been incorporated to increase the mechanical strength of these composites. Carbon nanotube composites are thus emerging as potential materials for artificial bone and bone regeneration in tissue engineering.

Keywords: carbon nanotubes, tissue engineering, extracellular matrix proteins, collagen, hyaluronic acid, stem cells

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