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Candida albicans keratitis in an immunocompromised patient

Authors Hassan M, Papanikolaou T, Mariatos G, Hammad A, Hassan H

Published 15 October 2010 Volume 2010:4 Pages 1211—1215


Review by Single-blind

Peer reviewer comments 1

H Mohammed J Hassan1, Theocharis Papanikolaou2, Georgios Mariatos1, Amany Hammad3, Hala Hassan4

1Ophthalmology Department, Barnsley Hospital NHS Foundation Trust, South Yorkshire, England, UK; 2Ophthalmology Department, Cambridge University Hospitals NHS Foundation Trust, England, UK; 3Ophthalmology Department, Rotherham Hospital NHS Foundation Trust, England, UK; 4Corneal and External Disease Service, Moorfields Eye Hospital NHS Foundation Trust, London, England, UK

Purpose: When investigating a case of unexplained corneal ulceration, we need to think of fungal infection and any predisposing factors.
Methods: A case study of a corneal ulceration in a patient who was HIV positive with a devastating visual outcome.
Results: Therapeutic corneal graft was necessary due to corneal perforation. Immunocompromised state of patient was retrospectively diagnosed.
Conclusions: Candida albicans keratitis is an opportunistic infection of a compromised cornea, and sometimes unknowingly compromised host, which can be initially misdiagnosed. Despite intensive antifungal therapy, occasionally patients require corneal grafting to improve vision, and before it is possible to establish an accurate diagnosis.

Keywords: fungal keratitis, corneal perforation, keratoplasty, human immunodeficiency virus, HIV

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