Back to Browse Journals » Therapeutics and Clinical Risk Management » Volume 2 » Issue 3

Cancer treatment-induced mucositis pain: strategies for assessment and management

Authors Debra J Harris

Published 15 September 2006 Volume 2006:2(3) Pages 251—258

Debra J Harris

 

Oregon Health Sciences University, Portland OR, USA

 

Abstract: Mucositis pain is a major clinical problem associated with cancer treatment. Mucosal tissue injury is a dose-limiting side effect and also limits nutritional intake and oral function, resulting in weight loss and nutritional deficits for many patients. The pathophysiology of mucositis is thought to be a complex array of cytokine-mediated events, which begins with mucosal atrophy and eventually leads to the painful ulceration of the mucosa. This article reviews current research related to pain management for mucositis. Effective treatment for mucositis pain must be targeted at the various factors involved in the pain experience. Although a number of interventions aimed to prevent and treat mucositis have been studied, there is little evidence to recommend any one treatment modality. While current strategies for pain management rely on general treatment for acute pain, research developments are aimed at targeting the specific receptors and enzymes involved in mucositis. As these breakthroughs become available clinically, thorough assessment and timely directed interventions must be implemented in order to limit patient distress from mucositis. This article presents an assessment tool specific to mucositis pain, including physical, functional, and pain parameters.

 

 

Keywords: mucositis, pain management, stomatitis, assessment

Download Article [PDF] 

Readers of this article also read:

A 41-year-old man with polyarthritis and severe autonomic neuropathy

Matthew E Bourcier, Aaron I Vinik

Therapeutics and Clinical Risk Management 2008, 4:837-842

Published Date: 8 August 2008

Resveratrol in prevention and treatment of common clinical conditions of aging

M Andrea Markus, Brian J Morris

Clinical Interventions in Aging 2008, 3:331-339

Published Date: 6 June 2008

Editorial || FREE PAPER ||

Garry M Walsh

Therapeutics and Clinical Risk Management 2007, 3:211-212

Published Date: 15 May 2007

Abatacept in the treatment of rheumatoid arthritis

Edward M Vital, Paul Emery

Therapeutics and Clinical Risk Management 2006, 2:365-375

Published Date: 15 December 2006

Cost-effectiveness of hypothetical new cancer drugs in patients with advanced small-cell lung cancer: results of a markov chain model

Carin A Uyl-de Groot, Joseph McDonnell, Guul ten Velde, David Radice, Harry J M Groen

Therapeutics and Clinical Risk Management 2006, 2:317-323

Published Date: 15 September 2006

Oral mucositis induced by anticancer treatments: physiopathology and treatments

D’Hondt, Lionel, Lonchay, Christophe, André, Marc, Canon, Jean-Luc

Therapeutics and Clinical Risk Management 2006, 2:159-168

Published Date: 15 June 2006

Treatment of pruritic diseases with topical calcineurin inhibitors

Sonja Ständer, Funda Schürmeyer-Horst, Thomas A Luger, Elke Weisshaar

Therapeutics and Clinical Risk Management 2006, 2:213-218

Published Date: 15 June 2006