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Cabozantinib for progressive metastatic medullary thyroid cancer: a review

Authors Colombo J, Wein R

Received 10 February 2014

Accepted for publication 19 March 2014

Published 28 May 2014 Volume 2014:10 Pages 395—404


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Joshua R Colombo, Richard O Wein

Department of Otolaryngology, Head and Neck Surgery, Tufts Medical Center, Boston, MA, USA

Abstract: Medullary thyroid cancer is uncommon and patients typically present with advanced disease. Treatment options for patients with progressive, metastatic medullary thyroid cancer had been limited until recently. Tyrosine kinase inhibitors have garnered increasing interest in this subset of patients. The US Food and Drug Administration recently approved cabozantinib, a tyrosine kinase inhibitor, after promising results were shown in a large Phase III clinical trial. This review summarizes the clinical pharmacology, clinical trials, and safety data for cabozantinib and concludes with a discussion of possible future directions for the treatment of medullary thyroid cancer.

Keywords: cabozantinib, tyrosine kinase inhibitor, medullary thyroid cancer

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