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Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations

Authors Patel SA, Hoffman-Censits J

Received 8 November 2016

Accepted for publication 24 July 2017

Published 17 August 2017 Volume 2017:10 Pages 4089—4098


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati

Sheel A Patel, Jean Hoffman-Censits

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA

Abstract: Cabazitaxel is an effective chemotherapeutic agent used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) refractory to docetaxel. With the advent of new antiandrogen therapies, immune-based treatments, and radioactive-targeted therapy, there are now multiple effective and approved agents for this disease state. The optimal sequencing of these agents is unclear as there are no large-scale head-to-head comparisons. Clinicians must familiarize themselves with the most recent studies as well as drug toxicities to determine the best treatment option for their patients. In this review, we focus on the development of cabazitaxel for mCRPC, evaluate its efficacy, and highlight key strategies for toxicity management. Additionally, we summarize the studies that address cabazitaxel treatment sequencing and optimal dosing schedule.

Keywords: sequencing, clinical trials, docetaxel, abiraterone, enzalutamide, biomarkers

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