Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

C-reactive protein levels in stable COPD patients: a case-control study

Authors Rossato Silva D, Gazzana M, Knorst M

Received 20 April 2015

Accepted for publication 16 June 2015

Published 31 August 2015 Volume 2015:10(1) Pages 1719—1725


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Editor who approved publication: Dr Richard Russell

Denise Rossato Silva,1,2 Marcelo Basso Gazzana,1,2 Marli Maria Knorst1,2

1Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, 2Department of Pulmonary Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Background: Previous studies have documented that C-reactive protein (CRP) levels are increased in stable COPD patients. However, most studies have also shown that higher CRP levels are observed in patients with comorbidities like diabetes mellitus and cardiovascular disease. We aimed to investigate if CRP levels are increased in stable COPD patients, and if there is an association between CRP levels and pulmonary function tests and clinical characteristics.
Methods: We conducted a case-control study in a tertiary care, university-affiliated hospital. COPD patients and controls were matched for sex and age in a 2:1 matching ratio. We included only those patients who had quit smoking. CRP levels were determined and pulmonary function tests were performed in both the groups.
Results: A total of 60 COPD patients and 30 controls were included in the analysis. The study subjects had a mean age of 64.8±8.5 years in COPD group and 64.3±9.2 years in control group (P=0.214). The median of CRP levels was 3.17 mg/L (interquartile range [IQR]: 1.73–5.99 mg/L) in COPD group and 2.13 mg/L (IQR: 1.18–7.69 mg/L) in control group (P=0.370). There were 34 (56.7%) patients in COPD group and 14 (46.7%) patients in control group with CRP levels greater than 3 mg/dL (P=0.382). Using bivariate correlations, we found significant positive correlations in COPD patients between body mass index (BMI) and CRP (r=0.3, P=0.045), and between CRP and forced vital capacity (FVC, % of predicted) (r=-0.3; P=0.023). In a multivariate model, female sex and FVC (% of predicted) were associated with a CRP value greater than 3 mg/dL in the COPD group.
Conclusion: The levels of CRP in the stable COPD patients were not significantly different when compared to those in the control subjects. Female sex and FVC (% predicted) were associated with CRP levels greater than 3 mg/dL in the COPD group.

Keywords: case-control study, chronic obstructive pulmonary disease, C-reactive protein, comorbidity

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

Posteroanterior chest X-ray for the diagnosis of pneumothorax: methods, usage, and resolution

Denise Rossato Silva, Sandra Jungblut Schuh, Paulo de Tarso Roth Dalcin

Reports in Medical Imaging 2010, 3:29-34

Published Date: 31 August 2010

Readers of this article also read:

Personalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease

Maekura R, Hiraga T, Miki K, Kitada S, Miki M, Yoshimura K, Yamamoto H, Kawabe T, Mori M

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1787-1800

Published Date: 3 September 2015

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

D’Urzo AD, Kerwin EM, Chapman KR, Decramer M, DiGiovanni R, D’Andrea P, Hu H, Goyal P, Altman P

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1599-1612

Published Date: 11 August 2015

Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report

Park TS, Hong Y, Lee JS, Oh SY, Lee SM, Kim N, Seo JB, Oh YM, Lee SD, Lee SW

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1501-1511

Published Date: 29 July 2015

Is dynamometry able to infer the risk of muscle mass loss in patients with COPD?

Ramos D, Bertolini GN, Leite MR, Carvalho Junior LCS, da Silva Pestana PR, Santos VR, Fortaleza ACS, Rodrigues FMM, Ramos EMC

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1403-1407

Published Date: 21 July 2015

Underdiagnosis and prognosis of chronic obstructive pulmonary disease after percutaneous coronary intervention: a prospective study

Almagro P, Lapuente A, Pareja J, Yun S, Garcia ME, Padilla F, Heredia JL, De la Sierra A, Soriano JB

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1353-1361

Published Date: 16 July 2015

Pulmonary hemodynamic profile in chronic obstructive pulmonary disease

Portillo K, Torralba Y, Blanco I, Burgos F, Rodriguez-Roisin R, Rios J, Roca J, Barberà JA

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1313-1320

Published Date: 14 July 2015