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Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability

Authors Anderson M

Received 16 October 2012

Accepted for publication 21 November 2012

Published 10 January 2013 Volume 2013:7 Pages 27—34

DOI https://doi.org/10.2147/PPA.S39233

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Mark Anderson

Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

Abstract: Prolonged seizures and status epilepticus are a common acute neurological presentation in pediatric practice. As a result, there is a need for effective and safe medications that can be delivered to convulsing children to effect rapid seizure termination both in hospital and community settings. The challenges of achieving intravenous access, particularly in young children, mandate alternative routes of administration for these drugs. Over the last ten years, midazolam delivered via the buccal mucosa has been demonstrated to be efficacious, safe, and acceptable to children and their caregivers, and a formulation has recently been licensed for use in Europe. The aim of this article is to review the clinical pharmacology with respect to these issues.

Keywords: pediatrics, neurology, pharmacology, buccal midazolam

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