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Brown–McLean syndrome: the role of iridodonesis

Authors Suwan Y, Teekhasaenee C, Lekhanont K, Supakontanasan W

Received 16 September 2015

Accepted for publication 31 December 2015

Published 15 April 2016 Volume 2016:10 Pages 671—677

DOI https://doi.org/10.2147/OPTH.S96507

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Wei Kun Hu

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Yanin Suwan, Chaiwat Teekhasaenee, Kaevalin Lekhanont, Wasu Supakontanasan

Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Purpose: The aim of this study was to report a case series of Brown–McLean syndrome (BMS).
Methods: The charts of 28 patients with BMS at Ramathibodi and Rutnin Hospital from 1981 to 2015 were reviewed.
Results: BMS is a rare condition with corneal edema involving the peripheral cornea with orange-brown pigment deposition underlying the edematous area. The edema typically starts inferiorly and advances circumferentially to superior cornea. Central cornea remains clear in most patients. We report 28 patients with BMS that occurred either spontaneously or after various intraocular procedures. Ultrasound biomicroscopy was performed to demonstrate the iridocorneal relationship.
Conclusion: Iridocorneal relationship from the ultrasound biomicroscopy study in four patients did not support previous hypothesis about the role of iridodonesis impact on corneal endothelium. Patients with BMS can rarely progress to corneal decompensation; however, they should be periodically monitored and made aware of early clinical signs of their complications.

Keywords: Brown–McLean syndrome, peripheral corneal edema, marginal corneal edema, corneal decompensation

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