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Bronchodilators for hyperinflation in COPD associated with biomass smoke: clinical trial

Authors Ramírez-Venegas A, Velázquez-Uncal M, Aranda-Chávez A, Guzmán-Bouilloud NE, Mayar-Maya ME, Pérez Lara-Albisua JL, Hernández-Zenteno RJ, Flores-Trujillo F, Sansores RH

Received 12 January 2019

Accepted for publication 12 April 2019

Published 6 August 2019 Volume 2019:14 Pages 1753—1762

DOI https://doi.org/10.2147/COPD.S201314

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell


Alejandra Ramírez-Venegas,1 Mónica Velázquez-Uncal,1 Adrián Aranda-Chávez,1 Nicolás Eduardo Guzmán-Bouilloud,1 María Eugenia Mayar-Maya,2 José Luis Pérez Lara-Albisua,1 Rafael de Jesus Hernández-Zenteno,3 Fernando Flores-Trujillo,3 Raúl H Sansores4

1Department of Tobacco Smoking and COPD Research, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosió Villegas”, Mexico City, Mexico; 2Department of Medical Attention, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosió Villegas”, Mexico City, Mexico; 3Obstructive Disease Ward, Pulmonary Obstructive Diseases Clinical Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico; 4Department of Respiratory Medicine, Medica Sur Clinic & Foundation, Mexico City, Mexico

Introduction: The efficacy of long-acting bronchodilators for COPD associated with biomass (BE-COPD) has not been properly evaluated.
Objective: To determine the acute effect of indacaterol (IND) 150 μg q.d and tiotropium (TIO) 18 μg q.d. on lung hyperinflation, walking distance (WD) and dyspnea during the six-minute walking test (6MWT) in moderate BE-COPD at 30, 60 and 240 mins post-drug administration.
Design: Randomized, controlled, open-level, crossover noninferiority clinical trial. Forty-two women with BE-COPD were randomly assigned to a bronchodilator sequence: IND–TIO or vice versa.
Results: There were statistically significant changes over time in inspiratory capacity (IC) (p<0.0001), FEV1 (p<0.0001) and FVC (p<0.0001) when IND was used. When TIO was administered, an increase over all time periods was observed only for FEV1 (p<0.0001) and FVC (p<0.0001), whereas for IC an increase was observed only at 30 mins and 24 hrs after TIO administration. We did not find clinically significant increases in WD and dyspnea after the administration of both bronchodilators.
Conclusion: Both IND and TIO showed significant and fast onset improvement in hyperinflation. Therefore, either of them may be recommended as a first line of treatment for COPD associated with BE-COPD.

Keywords: indacaterol, tiotropium, biomass exposure, inspiratory capacity, spirometry, six-minute walking test

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