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Broader implications: biological and clinical significance of microtubule acetylation

Authors Rymut S, Kelley T

Received 5 November 2014

Accepted for publication 3 December 2014

Published 23 January 2015 Volume 2015:7 Pages 71—82


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Professor Denis Wirtz

Sharon M Rymut,1,2 Thomas J Kelley1,2

1Department of Pharmacology, 2Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA

Abstract: Microtubule acetylation is a key posttranslational modification that enhances organelle transport, drives cell signaling, and regulates cell cycle regulation. The optimal level of microtubule acetylation is regulated by the acetyltransferase alpha-tubulin-N-acetyltransferase 1and two deacetylases, histone deacetylase 6 and sirtuin-2. Alterations in microtubule acetylation levels have been associated with the pathophysiology of a number of diseases, including various forms of neurodegenerative conditions, cancer, and even cystic fibrosis. In this review, we will highlight the biological and clinical significance of microtubule acetylation and the potential of targeting this pathway for therapeutics.

Keywords: microtubule, acetylation, HDAC6, MEC17, SIRT2, neurodegenerative disease, cancer, cystic fibrosis

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