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Brain metastases from breast cancer may respond to endocrine therapy: report of two cases

Authors Wang Q, Sun B, Liu C, Shi S, Ding L, Liu J, Wu S

Received 19 September 2018

Accepted for publication 31 December 2018

Published 19 February 2019 Volume 2019:12 Pages 1389—1393


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Sanjeev Srivastava

Qian Wang,* Bing Sun,* Chao Liu, Sanzhong Shi, Lijuan Ding, Jiannan Liu, Shikai Wu

Department of Radiation Oncology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China

*These authors contributed equally to this work

Abstract: Brain metastases from breast cancer have a poor prognosis. There have been few cases reported where patients with breast cancer and brain metastases respond well to endocrine therapy (tamoxifen or letrozole). Here, we report the cases of two breast cancer patients with brain metastases who responded to medroxyprogesterone acetate and fulvestrant, respectively. These cases indicate that endocrine therapy could be very effective in the management of brain metastases from breast carcinoma.

Keywords: breast cancer, brain metastases, endocrine therapy, medroxyprogesterone acetate, fulvestrant

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