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Brain in flames – animal models of psychosis: utility and limitations

Authors Mattei D, Schweibold R, Wolf S

Received 10 February 2015

Accepted for publication 31 March 2015

Published 27 May 2015 Volume 2015:11 Pages 1313—1329

DOI https://doi.org/10.2147/NDT.S65564

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder

Daniele Mattei,1 Regina Schweibold,1,2 Susanne A Wolf1

1Department of Cellular Neuroscience, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany; 2Department of Neurosurgery, Helios Clinics, Berlin, Germany

Abstract: The neurodevelopmental hypothesis of schizophrenia posits that schizophrenia is a psychopathological condition resulting from aberrations in neurodevelopmental processes caused by a combination of environmental and genetic factors which proceed long before the onset of clinical symptoms. Many studies discuss an immunological component in the onset and progression of schizophrenia. We here review studies utilizing animal models of schizophrenia with manipulations of genetic, pharmacologic, and immunological origin. We focus on the immunological component to bridge the studies in terms of evaluation and treatment options of negative, positive, and cognitive symptoms. Throughout the review we link certain aspects of each model to the situation in human schizophrenic patients. In conclusion we suggest a combination of existing models to better represent the human situation. Moreover, we emphasize that animal models represent defined single or multiple symptoms or hallmarks of a given disease.

Keywords: inflammation, schizophrenia, microglia, animal models
 

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