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Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

Authors Kanazawa T

Received 26 September 2014

Accepted for publication 28 October 2014

Published 6 January 2015 Volume 2015:8 Pages 57—64

DOI https://doi.org/10.2147/MDER.S70856

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Takanori Kanazawa

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

Abstract: Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we summarize our studies evaluating nose-to-brain delivery of drugs and small interfering ribonucleic acids in combination with cell-penetrating peptide-modified polymer micelles. Our findings show that the use of polymer micelles with surface modification with Tat peptide in the intranasal administration enables the non-invasive delivery of therapeutic agents to the brain by increasing the transfer of the administered drug or small interfering ribonucleic acid to the central nervous system from the nasal cavity.

Keywords: nose-to-brain, polymer micelles, cell-penetrating peptide, intranasal administration, nucleic acid

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