Back to Journals » International Journal of Nanomedicine » Volume 12

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Authors Han Y, Xu X, Tang J, Shen C, Lin Q, Chen H

Received 29 February 2016

Accepted for publication 5 August 2016

Published 20 December 2016 Volume 2017:12 Pages 127—135

DOI https://doi.org/10.2147/IJN.S107491

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Yuemei Han,1,* Xu Xu,1,* Junmei Tang,1,* Chenghui Shen,2 Quankui Lin,1,2 Hao Chen1,2

1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 2Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People’s Republic of China

*These authors contributed equally to this work

Abstract:
Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity. The coating of hydrophilic zwitterionic polymer effectively decreased the bioadhesion of lens epithelial cells or bacteria. In vivo intraocular implantation results showed good in vivo biocompatibility of zwitterionic IOL and its effectiveness against postoperative complications.

Keywords: RAFT, surface modification, endophthalmitis, PCO, in vivo

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]