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Botanics: a potential source of new therapies for Alzheimer's disease?

Authors Syad AN, Devi KP

Received 20 November 2013

Accepted for publication 23 January 2014

Published 3 April 2014 Volume 2014:4 Pages 11—26

DOI https://doi.org/10.2147/BTAT.S33554

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Arif Nisha Syad, Kasi Pandima Devi

Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India

Abstract: Alzheimer's disease is an age-related, complex neurodegenerative disorder characterized by loss of memory and impairment of multiple cognitive functions. Several factors contribute to the progression and development of the disease including amyloid beta accumulation, neurofibrillary tangle formation, cholinergic deficit, oxidative stress, neuroinflammation, and apoptosis. Numerous traditional and herbal medicinal plants have been used to treat several cognitive disorders including Alzheimer's disease. They act as excellent antioxidants, anti-inflammatory mediators, and cholinesterase and β-secretase inhibitors. In addition, these natural compounds also prevent the accumulation of amyloid beta and its fibril formation. Besides acting as core-molecules, these natural compounds act as a template for the production and synthesis of several drug leads with improved pharmacokinetic potentials and greater efficacies. Hence, herbal medicines that have interesting pharmacological effects with noticeable anti-Alzheimer's potential deserve increased attention for further development to drug entities. The present article reviews the botanical pharmacology with special reference to anti-Alzheimer activity of plants and plant-derived compounds.

Keywords: neurodegeneration, medicinal plants, antioxidants, Aβ peptide, neuroprotective, clinical trials

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