Back to Journals » Stem Cells and Cloning: Advances and Applications » Volume 2

Bone marrow mononuclear stem cells: potential in the treatment of myocardial infarction

Authors Leblond A, O’Sullivan J, Caplice N

Published 4 December 2009 Volume 2009:2 Pages 11—19


Review by Single anonymous peer review

Peer reviewer comments 4

Anne-Laure Leblond, John O’Sullivan, Noel Caplice

1Centre for Research in Vascular Biology (CRVB), Biosciences Institute, University College Cork, Cork, Ireland

Abstract: Despite advances in the management of myocardial infarction, congestive heart failure following myocardial infarction continues to be a major worldwide medical problem. Mononuclear cells from bone marrow are currently being studied as potential candidates for cellbased therapy to repair and regenerate damaged myocardium, with mixed results. The success of this strategy requires structural repair through both cardiomyogenesis and angiogenesis but also functional repair. However, pre-clinical and clinical studies with the intracoronary administration of cells indicate limited cardiomyogenesis and cell survival, controversial functional benefit and suggest paracrine effects mediated by the administered cells. Further investigations for optimizing therapeutic benefit focus on the requirement for stable cell engraftment and the involvement of cytokines in this process. This includes a large and varied range of strategies including cell or heart pre-treatment, tissue engineering and protein therapy. Although cellbased therapy holds promise in the future treatment of myocardial infarction, its current use is significantly hampered by biological and technological challenges.

Keywords: bone marrow mononuclear cells, myocardial infarction, cardiac cell therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]