Back to Journals » Virus Adaptation and Treatment » Volume 3

Boceprevir in the treatment of chronic hepatitis C virus infection

Authors Marina Berenguer, F Xavier López-Labrador

Published 22 February 2011 Volume 2011:3 Pages 7—17

DOI https://doi.org/10.2147/VAAT.S9677

Review by Single-blind

Peer reviewer comments 2

Marina Berenguer1, F Xavier López-Labrador2,3
1
Hepatology-Liver Transplantation Unit, Digestive Medicine Service, Hospital Universitari La Fe, and National Network Center for Hepatology and Gastroenterology Research, Instituto de Salud Carlos III, CIBEREHD Spain; 2CSISP, Center for Public Health Research, Public Health Department, Generalitat Valenciana and Microbioloy Department/Institut Cavanilles, University of Valencia, Valencia, Spain; 3National Network Center for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, CIBERESP Spain

Abstract: Chronic hepatitis C virus (HCV) infection is a global public health problem. The current standard-of-care treatment is effective in about 40%–50% of the cases, and the infection progresses to end-stage liver disease, hepatocellular carcinoma, and liver failure in a considerable number of infected individuals. After end-stage liver disease is established, the only reliable therapeutic intervention is liver transplantation. The urgent need for new, effective therapies is now focused on specific inhibitors of viral enzymes, among which inhibitors of the viral NS3/4A serine protease and NS5b RNA-dependent RNA polymerase are the most advanced in clinical development. In particular, telaprevir and boceprevir have entered several Phase III clinical trials after promising Phase II results. This review summarizes the preclinical and clinical development of boceprevir, one of the most important HCV NS3/4A protease inhibitors, and the eventual impact of this new inhibitor class for future HCV therapies.

Keywords: HCV, antiviral therapy, protease inhibitors, viral resistance

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Other article by this author:

New developments in the management of hepatitis C virus infection: focus on boceprevir

Berenguer M, López-Labrador FX

Biologics: Targets and Therapy 2012, 6:249-256

Published Date: 3 August 2012

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Acquired hemophilia A: emerging treatment options

Janbain M, Leissinger CA, Kruse-Jarres R

Journal of Blood Medicine 2015, 6:143-150

Published Date: 8 May 2015

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Second case report of successful electroconvulsive therapy for a patient with schizophrenia and severe hemophilia A

Saito N, Shioda K, Nisijima K, Kobayashi T, Kato S

Neuropsychiatric Disease and Treatment 2014, 10:865-867

Published Date: 16 May 2014

Managing hemophilia: the role of mobile technology

Khair K, Holland M

Smart Homecare Technology and TeleHealth 2014, 2:39-44

Published Date: 6 May 2014

Corrigendum

Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP

International Journal of Nanomedicine 2012, 7:1709-1710

Published Date: 30 March 2012