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Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies

Authors Dosanjh A, Lew KP

Received 27 February 2019

Accepted for publication 3 July 2019

Published 31 July 2019 Volume 2019:12 Pages 213—215

DOI https://doi.org/10.2147/JAA.S207015

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Luis Garcia-Marcos


Amrita Dosanjh,1 Kaitlyn P Lew2

1Pediatric Respiratory, San Diego, CA, USA; 2Brown University, Providence, RI, USA

Abstract: The use of immunosuppressive treatments and their related gastrointestinal adverse effects have been implicated in the development of food allergic responses following transplantation. There is limited information on the pathogenesis of the food allergic immune response among umbilical cord transplantation recipients. This study was conducted to identify a cohort of food allergic umbilical cord recipients in the literature. The literature was searched to systematically identify this cohort. Criteria for inclusion included umbilical cord transplantation, food allergic response, and reported laboratory data. Analysis of the laboratory data using the Pearson method revealed that there was a moderate negative correlation with a coefficient of r=−0.7016 and r2=−0.49 between peripheral eosinophilia and serum immunoglobulin E (IgE) levels. Future studies on a larger population are needed, but this study may help to elucidate possible cellular mechanisms involved in this response.

Keywords: GVHD, tacrolimus, cord blood, stem cell

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