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Blocking rhinoviral adhesion molecule (ICAM-1): potential to prevent COPD exacerbations

Authors Shukla SD, Hansbro PM, Walters EH

Received 1 April 2017

Accepted for publication 13 April 2017

Published 11 May 2017 Volume 2017:12 Pages 1413—1414

DOI https://doi.org/10.2147/COPD.S138612

Checked for plagiarism Yes

Editor who approved publication: Dr Richard Russell

Shakti Dhar Shukla,1–3 Philip Michael Hansbro,1–3 Eugene Haydn Walters4

1Priority Research Centre for Healthy Lungs, 2School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW, Australia; 3Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; 4School of Medicine, University of Tasmania, Hobart, TAS, Australia

Acute exacerbations of COPD (AECOPD) are markers of disease progression and severity, and frequently are used as an outcome variable in interventional studies.1 AECOPD results in increased severity of symptoms and induces disease progression with accelerated decline in lung function and decreased quality of life. The risk of morbidity and mortality is also significantly increased. Most AECOPD (~85%) have an infectious etiology, induced by bacteria and viruses, often rhinovirus (~50%).1

View the original paper by Johnston and colleagues.

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