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Biosynthesis, characterization, and evaluation of bioactivities of leaf extract-mediated biocompatible silver nanoparticles from an early tracheophyte, Pteris tripartita Sw.

Authors Baskaran XR, Geo Vigila AV, Parimelazhagan T, Muralidhara-Rao D, Zhang SZ

Received 10 March 2016

Accepted for publication 18 June 2016

Published 14 November 2016 Volume 2016:11 Pages 5789—5806

DOI https://doi.org/10.2147/IJN.S108208

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Linlin Sun


Xavierravi Baskaran,1 Antony Varuvel Geo Vigila,2 Thangaraj Parimelazhagan,3 Doulathabad Muralidhara-Rao,4 Shouzhou Zhang1

1Shenzhen Key Laboratory of Southern Subtropical Plant Diversity, Fairy Lake Botanical Garden, Shenzhen and Chinese Academy of Sciences, Shenzhen, People’s Republic of China; 2Department of Zoology, St Xavier’s College, Palayamkottai, 3Department of Botany, Bioprospecting Laboratory, Bharathiar University, Coimbatore, Tamil Nadu, 4Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India

Abstract: The objective of the study was to characterize silver nanoparticles (Ag-NPs) and their bioactivities in early tracheophytes (Pteridophyta). Aqueous leaf extract of a critically endangered fern, Pteris tripartita Sw., was used for one-step green synthesis of Ag-NPs. The biosynthesized Ag-NPs were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and high-resolution transmission electron microscopy. Morphologically, the Ag-NPs showed hexagonal, spherical, and rod-shaped structures. Size distributions of Ag-NPs, calculated using Scherrer’s formula, showed an average size of 32 nm. Ag-NPs were studied for in vitro antioxidant, antimicrobial, and in vivo anti-inflammatory activities. Ag-NPs exhibited significant anti-inflammatory activity in carrageenan-induced paw volume tests performed in female Wistar albino rats. Furthermore, Ag-NPs showed significant antimicrobial activity against 12 different microorganisms in three different assays (disk diffusion, time course growth, and minimum inhibitory concentration). This study reports that colloidal Ag-NPs can be synthesized by simple, nonhazardous methods, and that biosynthesized Ag-NPs have significant therapeutic properties.

Keywords: silver nanoparticles, Pteris tripartita, FTIR, HRTEM, antioxidant, antimicrobial

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