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Biomarkers in fibromyalgia: a review

Authors Giacomelli C, Sernissi F, Rossi A, Bombardieri S, Bazzichi L

Received 15 November 2013

Accepted for publication 8 January 2014

Published 21 February 2014 Volume 2014:4 Pages 35—41

DOI https://doi.org/10.2147/CBF.S38161

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Camillo Giacomelli,* Francesca Sernissi,* Alessandra Rossi, Stefano Bombardieri, Laura Bazzichi

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

*These authors contributed equally to the manuscript

Abstract: Fibromyalgia is a common syndrome diagnosed by clinical criteria. The main symptom of fibromyalgia is pain, but patients frequently also complain about other nonspecific symptoms, such as headache, sleep disturbance, mood disorder, and cognitive impairment. In the light of the multifactorial origin of the disease and of the lack of objective diagnostic findings, several attempts have been made to find a reliable biomarker. For this reason, over the years, a number of patients and various biological samples have been studied, using many different approaches and techniques. Despite this, none of these studies has been able to find the proper biomarker. The aim of this review is to provide a critical overview of the current environment characterizing the search for fibromyalgia biomarkers.

Keywords: genetics, proteomics, oxidative stress, fibromyalgia

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