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Biomarkers for the prediction of acute ongoing arterial plaque rupture

Authors Guo Y, Li J

Received 17 February 2013

Accepted for publication 7 May 2013

Published 12 July 2013 Volume 2013:4 Pages 107—113


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Yuan-Lin Guo, Jian-Jun Li

Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

Abstract: Acute coronary syndrome (ACS) is the main cause of mortality for coronary artery disease (CAD). Accordingly, earlier detection and diagnosis might be a key point for reducing the mortality in patients with ACS. One promising strategy is biomarker measurement in patients with ACS. Biomarkers are generally considered to be plasma measurements of molecules, proteins, or enzymes that provide independent diagnostic and prognostic values that can reflect underlying disease state and condition, especially repeated measurements. Nowadays, the most widely used biomarkers to identify or predict ACS are high sensitivity C-reactive protein (hs-CRP) and high sensitivity troponin T/I (hs-TnT/I). The aim of the present review was principally to summarize recent evidence regarding some new biomarkers by which we could directly predict acute ongoing arterial plaque rupture, which may help to identify at-risk patients earlier than hs-CRP or hs-TnT/I.

Keywords: matrix metalloproteinase-9, lipoprotein associated phospholipase A2, myeloperoxidase, soluble lectin-like oxidized low-density lipoprotein receptor-1, pregnancy-associated plasma protein A, placental growth factor, acute coronary syndrome

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