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Biomarker and competing endogenous RNA potential of tumor-specific long noncoding RNA in chromophobe renal cell carcinoma

Authors He HT, Xu M, Kuang Y, Han XY, Wang MQ, Yang Q

Received 4 July 2016

Accepted for publication 20 September 2016

Published 18 October 2016 Volume 2016:9 Pages 6399—6406

DOI https://doi.org/10.2147/OTT.S116392

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ru Chen

Peer reviewer comments 4

Editor who approved publication: Dr William Cho


Hai-Tao He,1,2,* Mu Xu,1,* Ye Kuang,1 Xiao-Yun Han,1 Ming-Qi Wang,1 Qing Yang1

1Department of Pathogenobiology, 2Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun, People’s Republic of China

*These authors contributed equally to this work

Background: Accumulating evidence suggests long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of cancers. However, their functions in chromophobe renal cell carcinoma (chRCC) are not fully understood.
Methods: We analyzed the expression profiles of lncRNA, microRNA, and protein-coding RNA, along with the clinical information of 59 primary chRCC patients collected from The Cancer Genome Atlas database to identify lncRNA biomarkers for prognosis. We also constructed an lncRNA–microRNA–mRNA coexpression network (competitive endogenous RNAs network) by bioinformational approach.
Results: One hundred and forty-two lncRNAs were found to be differentially expressed between the cancer and normal tissues (fold change ≥1.5, P<0.001). Among them, 12 lncRNAs were also differentially expressed with the corresponding clinical characteristics (fold change ≥1.5, P<0.01). Besides, 7 lncRNAs (COL18A1-AS, BRE-AS1, SNHG7, TMEM51-AS1, C21orf62-AS1, LINC00336, and LINC00882) were identified to be significantly correlated with overall survival (log-rank P<0.05). A competitive endogenous RNA network in chRCC containing 16 lncRNAs, 18 miRNAs, and 168 protein-coding RNAs was constructed.
Conclusion: Our results identified specific lncRNAs associated with chRCC progression and prognosis, and presented competing endogenous RNA potential of lncRNAs in the tumor.

Keywords: long noncoding RNA, chromophobe renal cell carcinoma, biomarker, competing endogenous RNA network
 

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