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Biologics: the role of delivery systems in improved therapy

Authors Škalko-Basnet N

Received 21 December 2013

Accepted for publication 3 February 2014

Published 19 March 2014 Volume 2014:8 Pages 107—114

DOI https://doi.org/10.2147/BTT.S38387

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Nataša Škalko-Basnet

Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø, Norway

Abstract: The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side effects. In addition, they exhibit more predictable behavior under in vivo conditions. However, up to now most of the formulations of biologics are designed and destined for the parenteral route of administration. As a consequence, many suffer from short plasma half-lives, resulting in their frequent administration and ultimately poor patient compliance. This review represents an attempt to address some of the challenges and promises in the product development of biologics both for parenteral and noninvasive administration. Some of the products currently in the pipeline of pharmaceutical development and corresponding perspectives are discussed in more detail.

Keywords: biologics, drug delivery systems, medical devices

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