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Biofunctionalization of biomaterials for nitric oxide delivery: potential applications in regenerative medicine

Authors Tsai KJ, Rammou A, Gao C, de Mel A

Received 25 June 2017

Accepted for publication 10 April 2018

Published 27 August 2018 Volume 2018:4 Pages 25—36


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Gozde Durmus

Kai Jen Tsai,1,* Anna Rammou,1,* Chuanyu Gao,1 Achala de Mel1,2

1UCL Division of Surgery and Interventional Sciences, University College London, London, UK; 2School of Chemistry, University of Nottingham, Nottingham, UK

*These authors contributed equally to this work

Introduction: Mimicking physiological functions of nitric oxide (NO) has applications in regenerative medicine. However, few NO delivery systems have progressed to clinical trials owing to limitations in delivery.
Materials and methods: A novel NO delivery system was explored by integrating S-nitro-N-acetylpenicillamine-functionalized long-chain aliphatic hydrocarbons (LCAHs) into a polyurethane-based polymer.
Results and discussion: Contact angle analysis determined the novel delivery system to be significantly more hydrophobic than control. Chemilluminscence showed a four-phase NO release profile of the delivery system with more stable and prolong NO release than control.
Conclusion: LCAHs can optimize the duration and rate of NO delivery and present a viable option for use in surgical implants and biomedical applications.

Keywords: nitric oxide, biofunctionalization, materials, aliphatic hydrocarbons

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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