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Biofunctionalization of biomaterials for nitric oxide delivery: potential applications in regenerative medicine

Authors Tsai KJ, Rammou A, Gao C, de Mel A

Received 25 June 2017

Accepted for publication 10 April 2018

Published 27 August 2018 Volume 2018:4 Pages 25—36

DOI https://doi.org/10.2147/AHCT.S144816

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Gozde Durmus


Kai Jen Tsai,1,* Anna Rammou,1,* Chuanyu Gao,1 Achala de Mel1,2

1UCL Division of Surgery and Interventional Sciences, University College London, London, UK; 2School of Chemistry, University of Nottingham, Nottingham, UK

*These authors contributed equally to this work

Introduction: Mimicking physiological functions of nitric oxide (NO) has applications in regenerative medicine. However, few NO delivery systems have progressed to clinical trials owing to limitations in delivery.
Materials and methods: A novel NO delivery system was explored by integrating S-nitro-N-acetylpenicillamine-functionalized long-chain aliphatic hydrocarbons (LCAHs) into a polyurethane-based polymer.
Results and discussion: Contact angle analysis determined the novel delivery system to be significantly more hydrophobic than control. Chemilluminscence showed a four-phase NO release profile of the delivery system with more stable and prolong NO release than control.
Conclusion: LCAHs can optimize the duration and rate of NO delivery and present a viable option for use in surgical implants and biomedical applications.

Keywords: nitric oxide, biofunctionalization, materials, aliphatic hydrocarbons

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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