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Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process

Authors Huang Y, Shen X, Qiao HX, Yang H, Zhang XJ, Liu YY, Yang HJ

Received 1 August 2017

Accepted for publication 7 December 2017

Published 31 January 2018 Volume 2018:13 Pages 633—640

DOI https://doi.org/10.2147/IJN.S147969

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 3

Editor who approved publication: Dr Linlin Sun


Yong Huang,1,* Xue Shen,2,* Haixia Qiao,1 Hao Yang,3 Xuejiao Zhang,1 Yiyao Liu,2 Hejie Yang4

1College of Lab Medicine, Hebei North University, Zhangjiakou, 2School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 3Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 4State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an, China

*These authors contributed equally to this work


Background: Two frequent problems associated with titanium (Ti) surfaces of bone/dental implants are their corrosion and lack of native tissue integration.
Methods: Here, we present an anodization-hydrothermal method for coating Ti surfaces with a layer of silicon (Si)- and strontium (Sr)-loaded titania nanotubes (TNs). The Ti surfaces coated with such a layer (Si–Sr-TNs) were characterized with different techniques.
Results: The results indicate that the Si4+ and Sr2+ ions were evenly incorporated into the TNs and that the Si–Sr-TN layer provides good protection against corrosive media like simulated body fluid. The excellent cytocompatibility of the coating was confirmed in vitro by the significant growth and differentiation of MC3T3-E1 osteoblastic cells.
Conclusion: Being easily and economically fabricated, the Si–Sr-TN surfaces may find their niche in clinical applications, thanks to their excellent biological activity and corrosion resistance.

Keywords: TiO2 nanotube, silicon, strontium, cytocompatibility, corrosion resistance

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