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Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions

Authors Zhang S, Xia L, Ding C, Wen L, Wan W, Chen G

Received 29 January 2016

Accepted for publication 13 April 2016

Published 13 June 2016 Volume 2016:11 Pages 2769—2784

DOI https://doi.org/10.2147/IJN.S105339

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Shichang Zhang, Liye Xia, Chenchen Ding, Lu Wen, Weihua Wan, Gang Chen

Department of Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China

Abstract:
Hydrogen peroxide (H2O2) functions as an early damage signal contributing to the oxidative stress response and can act as a trigger in smart oxidation-responsive drug delivery systems that are currently in development. Current H2O2-triggered oxidation-responsive polymeric systems are usually derived from chemical synthesis and rarely include natural polymers. Herein, we report two series of nanoparticle (NP) complexes prepared with the biopolymer chitosan (CS) and four different metal ions (Cu2+, Ca2+, Zn2+, and Fe3+), defined as CSNPs-metal complexes (Series 1) and CS-metal complexes NPs (Series 2), which responded to oxidation by dissolving upon H2O2 exposure. Experiments examining Nile red release and H2O2-triggered degradation confirmed that both series of complexes showed better sensitivity to oxidation than the CSNPs alone. Furthermore, preliminary cytotoxicity and histological observations indicated that the two series exhibited little or no cytotoxicity and generated a mild inflammatory response. Our work provides a novel and promising strategy for developing NPs for use as intelligent oxidation-responsive systems.

Keywords: oxidation-responsive system, chitosan, nanoparticles, hydrogen peroxide, metal complexes

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