Bio-physic constraint model using spatial registration of delta 18F-fluorodeoxyglucose positron emission tomography/computed tomography images for predicting radiation pneumonitis in esophageal squamous cell carcinoma patients receiving neoadjuvant chemoradiation
Received 18 February 2019
Accepted for publication 12 July 2019
Published 13 August 2019 Volume 2019:12 Pages 6439—6451
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Jyoti Bajaj
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Nicola Silvestris
Tien-Chi Hou,1 Kun-Yao Dai,1 Ming-Che Wu,2 Kai-Lung Hua,3 Hung-Chi Tai,1 Wen-Chien Huang,4 Yu-Jen Chen1,5
1Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan; 2Department of Nuclear Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 3Department of Computer Science and Information Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 4Department of Surgery, Division of Thoracic Surgery, Mackay Memorial Hospital, Taipei City 10449, Taiwan; 5Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan
Purpose: This study integrated clinical outcomes and radiomics of advanced thoracic esophageal squamous cell carcinoma patients receiving neoadjuvant concurrent chemoradiotherapy (NACCRT) to establish a novel constraint model for predicting radiation pneumonitis (RP).
Patients and methods: We conducted a retrospective review for thoracic advanced esophageal cancer patients who received NACCRT. From 2013 to 2018, 89 patients were eligible for review. Staging workup and response evaluation included positron emission tomography/computed tomography (PET/CT) scans and endoscopic ultrasound. Patients received RT with 48 Gy to gross tumor and 43.2 Gy to elective nodal area in simultaneous integrated boost method divided in 24 fractions. Weekly platinum-based chemotherapy was administered concurrently. Side effects were evaluated using CTCAE v4. Images of 2-fluoro-2-deoxyglucose PET/CT before and after NACCRT were registered to planning CT images to create a region of interest for dosimetry parameters that spatially matched RP-related regions, including V10, V20, V50%, V27, and V30. Correlation between bio-physic parameters and toxicity was used to establish a constraint model for avoiding RP.
Results: Among the investigated cohort, clinical downstaging, complete pathological response, and 5-year overall survival rates were 59.6%, 40%, and 34.4%, respectively. Multivariate logistic regression analysis demonstrated that each individual set standardized uptake value ratios (SUVRs), neither pre- nor post-NACCRT, was not predictive. Interestingly, cutoff increments of 6.2% and 8.9% in SUVRs (delta-SUVR) in registered V20 and V27 regions were powerful predictors for acute and chronic RP, respectively.
Conclusion: Spatial registration of metabolic and planning CT images with delta-radiomics analysis using fore-and-aft image sets can establish a unique bio-physic prediction model for avoiding RP in esophageal cancer patients receiving NACCRT.
Keywords: esophageal cancer, neoadjuvant concurrent chemoradiation, radiation pneumonitis, PET/CT, constraint model
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