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Binding fullerenol C60(OH)24 to dsDNA

Authors Mariana Pinteala, Andrei Dascalu, Cezar Ungurenasu

Published 8 September 2009 Volume 2009:4 Pages 193—199

DOI https://doi.org/10.2147/IJN.S6630

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Mariana Pinteala, Andrei Dascalu, Cezar Ungurenasu

Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, Iasi, Romania

Abstract: The first C60(OH)24-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C60(OH)24 is in proportion to the concentration of DNA in the range of 1 × 10-9 to 8 × 10-5 molL-1 and the detection limit was 1.3 ng mL-1. Fullerenol C60(OH)24 binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.

Keywords: nanomedicine, fullerenol, DNA complexation, fluorescent probe

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