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Bilateral inferior petrosal sinus sampling in the diagnosis of Cushing disease

Authors Deipolyi A, Oklu R

Received 14 December 2014

Accepted for publication 3 March 2015

Published 16 April 2015 Volume 2015:3 Pages 1—7


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Alexander Verin

Amy R Deipolyi,1 Rahmi Oklu2

1Vascular and Interventional Radiology, NYU Langone Medical Center, New York, NY, USA; 2Division of Vascular and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Abstract: Bilateral inferior petrosal sinus sampling (BIPSS) is a minimally invasive procedure performed in the workup of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome (CS). Because noninvasive tests in the evaluation of CS patients lack sensitivity, BIPSS is the gold standard in diagnosing Cushing disease (CD), which is a pituitary source of excess ACTH. Here, the pathophysiology of CD and procedural details of BIPSS are reviewed.

Keywords: pituitary adenoma, Cushing disease, inferior petrosal sinus, venous sampling

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