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Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction

Authors Oleñik A, Mahillo-Fernández I, Alejandre-Alba N, Fernández-Sanz G, Pérez M, Luxan S, Quintana S, de Carneros Llorente AM, García-Sandoval B, Jiménez-Alfaro I

Received 14 February 2014

Accepted for publication 20 March 2014

Published 30 April 2014 Volume 2014:8 Pages 831—836

DOI https://doi.org/10.2147/OPTH.S62470

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Andrea Oleñik, Ignacio Mahillo-Fernández, Nicolás Alejandre-Alba, Guillermo Fernández-Sanz, María Alarcón Pérez, Sol Luxan, Silvia Quintana, Alfonso Martínez de Carneros Llorente, Blanca García-Sandoval, Ignacio Jiménez-Alfaro

Department of Ophthalmology, Fundación Jiménez Díaz, Madrid, Spain

Background: We assessed the impact of a dietary supplement based on the combination of omega-3 essential fatty acids and antioxidants on health-related quality of life in patients with meibomian gland dysfunction (MGD).
Methods: Patients of either sex (aged 18–85 years) diagnosed with MGD according to criteria identified at a 2011 International Workshop on Meibomian Gland Dysfunction participated in this randomized, double-masked, placebo-controlled study. Group A patients (controls) received an oral placebo supplement and group B patients received the oral study supplement (Brudysec® 1.5 g; Brudy Laboratories, Barcelona, Spain). At baseline and at 3-month follow-up, the patients completed the 36-Item Short Form Health Survey questionnaire using a Spanish validated version. The Physical (PCS) and Mental (MCS) Component Summary scores were the main outcome variables.
Results: A total of 61 patients completed the study (group A, n=31; group B, n=30). There were no significant differences in PCS and MCS scores at baseline between the two study groups, but after 3 months of treatment, significantly higher mean PCS and MSC scores were observed in patients treated with the active omega-3 dietary supplement as compared with controls (mean [standard deviation] PCS score 53.33±5.57 versus 47.46±7.31, P=0.008; mean MCS score 54.60±5.64 versus 47.80±8.45, P=0.0005). Moreover, mean differences between values at 3 months as compared with baseline were statistically significant for patients in group B (PCS score 7.14±5.81, 95% confidence interval 4.97–9.31, P=0.000; MCS score 5.96±7.64, 95% confidence interval 3.10–8.81, P=0.0002), whereas mean differences in patients assigned to group A were not statistically significant.
Conclusion: Dietary supplementation with a combination of omega-3 essential fatty acids and antioxidants had a significant beneficial effect on HRQoL (health-related quality of life) in patients with MGD.

Keywords: antioxidants, Brudysec®, nutraceuticals, polyunsaturated fatty acids

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