Back to Journals » Therapeutics and Clinical Risk Management » Volume 3 » Issue 4

Bacteremia and endocarditis due to methicillin-resistant Staphylococcus aureus: the potential role of daptomycin

Authors David M Bamberger

Published 15 September 2007 Volume 2007:3(4) Pages 675—684

David M Bamberger

University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

Abstract: Staphylococcus aureus bacteremia is a common disease with a high risk of mortality and complications. An increasing proportion of cases are methicillin-resistant S.aureus (MRSA), and methicillin-resistance is being observed from both community-acquired bacteremias and in healthcare-associated infections. The duration of bacteremia and transesophageal echocardiographic findings are useful in predicting the likelihood of complications including endocarditis. Therapy with vancomycin has been the mainstay in the treatment of MRSA bacteremias, but is associated with a long duration of bacteremia on therapy and relapses. Loss of susceptibility to vancomycin, due to thickened cell walls and through the acquisition of the vanA gene, has been described. Daptomycin is newly approved lipopeptide that is highly bactericidal against most strains of MRSA. In a randomized trial, daptomycin was demonstrated to be effective in the treatment of S. aureus bacteremia and right-sided endocarditis. However treatment failures associated with isolates with daptomycin non-susceptibility are reported, and there is a correlation between isolates with reduced vancomycin susceptibility and reduced daptomycin susceptibility. Daptomycin is a useful alternative to vancomycin in the therapy of MRSA bacteremia and endocarditis. However the appropriate role of daptomycin in optimizing therapy with MRSA bacteremia and endocarditis remains to be elucidated.

Keywords: methicillin-resistant Staphylococcus aureus, bacteremia, endocarditis, daptomycin

Download Article [PDF] 

Readers of this article also read:

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH

Drug Design, Development and Therapy 2015, 9:6483-6488

Published Date: 21 December 2015

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

El-Shazly AN, Ibrahim SA, El-Mashad GM, Sabry JH, Sherbini NS

International Journal of Nephrology and Renovascular Disease 2015, 8:159-163

Published Date: 10 December 2015

Lung ultrasound for the diagnosis of childhood pneumonia: a safe and accurate imaging mode

Hendaus MA, Jomha FA, Alhammadi AH

Therapeutics and Clinical Risk Management 2015, 11:1817-1818

Published Date: 9 December 2015

Clinicopathological significance of CXCR4 in non-small cell lung cancer

Zhou X, He L, Hou G, Jiang B, Wang Y, Zhao L

Drug Design, Development and Therapy 2015, 9:1349-1358

Published Date: 5 March 2015

Narrative review of telemedicine consultation in medical practice

Di Cerbo A, Morales-Medina JC, Palmieri B, Iannitti T

Patient Preference and Adherence 2015, 9:65-75

Published Date: 13 January 2015

Falls and cognitive decline in Mexican Americans 75 years and older

Padubidri A, Al Snih S, Samper-Ternent R, Markides KS, Ottenbacher KJ, Raji MA

Clinical Interventions in Aging 2014, 9:719-726

Published Date: 22 April 2014

Action of irbesartan on blood pressure and glucose/lipid metabolism, in hemodialysis patients with hypertension

Onishi A, Morishita Y, Watanabe M, Numata A, Tezuka M, Okuda K, Tsunematsu S, Sugaya Y, Hashimoto S, Kusano E

International Journal of General Medicine 2013, 6:405-411

Published Date: 28 May 2013

Echographic detectability of optoacoustic signals from low-concentration PEG-coated gold nanorods

Conversano F, Soloperto G, Greco A, Ragusa A, Casciaro E, Chiriacò F, Demitri C, Gigli G, Maffezzoli A, Casciaro S

International Journal of Nanomedicine 2012, 7:4373-4389

Published Date: 9 August 2012

A review of the use of adapalene for the treatment of acne vulgaris

Suleyman Piskin, Erol Uzunali

Therapeutics and Clinical Risk Management 2007, 3:621-624

Published Date: 15 September 2007