Back to Journals » Drug Design, Development and Therapy » Volume 5

Available and emerging treatments for Parkinson’s disease: a review

Authors Hickey P, Stacy M

Published 2 May 2011 Volume 2011:5 Pages 241—254


Review by Single anonymous peer review

Peer reviewer comments 3

Download Article [PDF] 

Patrick Hickey, Mark Stacy
Division of Neurology, Duke University Medical Center, Durham, NC, USA

Abstract: Parkinson’s disease is a commonly encountered neurodegenerative disorder primarily found in aged populations. A number of medications are available to control symptoms, although these are less effective in advanced disease. Deep brain stimulation provides a practicable alternative at this stage, although a minority of patients meet the strict criteria for surgery. Novel medications that provide enhanced symptomatic control remain in developmental demand. Both gene and cell-based therapies have shown promise in early clinical studies. A major unmet need is a treatment that slows or stops disease progression.

Keywords: Parkinson’s disease, levodopa, motor fluctuations, adenosine A2A antagonists, deep brain stimulation, gene therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]