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Available and emerging treatments for Parkinson’s disease: a review

Authors Hickey P, Stacy M

Published 2 May 2011 Volume 2011:5 Pages 241—254

DOI https://doi.org/10.2147/DDDT.S11836

Review by Single-blind

Peer reviewer comments 3


Patrick Hickey, Mark Stacy
Division of Neurology, Duke University Medical Center, Durham, NC, USA

Abstract: Parkinson’s disease is a commonly encountered neurodegenerative disorder primarily found in aged populations. A number of medications are available to control symptoms, although these are less effective in advanced disease. Deep brain stimulation provides a practicable alternative at this stage, although a minority of patients meet the strict criteria for surgery. Novel medications that provide enhanced symptomatic control remain in developmental demand. Both gene and cell-based therapies have shown promise in early clinical studies. A major unmet need is a treatment that slows or stops disease progression.

Keywords: Parkinson’s disease, levodopa, motor fluctuations, adenosine A2A antagonists, deep brain stimulation, gene therapy

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