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Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

Authors Dash S, Chava S, Chandra P, Aydin Y, Balart L, Wu T

Received 22 August 2015

Accepted for publication 30 November 2015

Published 22 February 2016 Volume 2016:8 Pages 9—20

DOI https://doi.org/10.2147/HMER.S63700

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Gerry Lake-Bakaar


Srikanta Dash,1,2 Srinivas Chava,1 Partha K Chandra,1 Yucel Aydin,2 Luis A Balart,2 Tong Wu1

1Department of Pathology and Laboratory Medicine, 2Department of Gastroenterology and Hepatology, Tulane University School of Medicine, New Orleans, LA, USA

Abstract: Autophagy is an intracellular lysosomal degradation process performed by the cells to maintain energy balance. The autophagy response plays an important role in the progression of liver disease due to hepatitis virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, liver cirrhosis, and hepatocellular carcinoma (HCC). An increased autophagy response also contributes to the pathogenesis of liver disease through modulation of innate and adaptive immune responses; a defective cellular autophagy response leads to the development of HCC. Recent progress in the field indicates that autophagy modulation provides a novel targeted therapy for human liver cancer. The purpose of this review is to update our understanding of how the cellular autophagy response impacts the pathophysiology of liver disease and HCC treatment.

Keywords: hepatocellular carcinoma, macroautophagy, microautophagy, autophagy inhibitor, chloroquine, hydroxychloroquine, sorafenib

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