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Atypical Ulcers: Diagnosis and Management

Authors Janowska A, Dini V, Oranges T, Iannone M, Loggini B, Romanelli M

Received 21 September 2019

Accepted for publication 16 November 2019

Published 10 December 2019 Volume 2019:14 Pages 2137—2143

DOI https://doi.org/10.2147/CIA.S231896

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Agata Janowska,1 Valentina Dini,1 Teresa Oranges,1,2 Michela Iannone,1 Barbara Loggini,3 Marco Romanelli1

1Department of Dermatology, University of Pisa, Pisa, Italy; 2Department of Health Sciences, Anna Meyer Children University Hospital, University of Florence, Florence, Italy; 3Department of Pathology, University of Pisa, Pisa, Italy

Correspondence: Agata Janowska
Department of Dermatology, University of Pisa, Via Roma 67, Pisa 56126, Italy
Tel +39 050 992436
Fax +39 050 992556
Email dottoressajanowska@gmail.com

Abstract: Atypical ulcers show atypical clinical features, histology, localization, and resistance to standard therapies. The persistence of a chronic ulcer despite treatment with standard therapies requires a more specific diagnostic investigation. Diagnosis involves obtaining the history and performing clinical examination and additional tests. A skin biopsy is frequently used to confirm unclear diagnosis. In difficult cases, microbiological and immunohistochemical examinations, laboratory blood tests, or instrumental tests should be evaluated. The treatment of atypical wounds is characterized by local systemic therapy and pain control. Our results highlight the need for early diagnosis, and standardized and targeted management by a multidisciplinary wound healing center.

Keywords: atypical ulcers, wound healing, wound bed preparation, wound management

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