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Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia

Authors Guzel D, Yazici AB, Mutu Pek T, Doganay S, Saykan Simsek AB, Saglam K, Turan C, Yazici E

Received 29 March 2018

Accepted for publication 16 May 2018

Published 16 July 2018 Volume 2018:14 Pages 1855—1860

DOI https://doi.org/10.2147/NDT.S169619

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Derya Guzel,1 Ahmet Bulent Yazici,2 Tugba Mutu Pek,2 Songul Doganay,1 Alime Burcin Saykan Simsek,2 Kadir Saglam,1 Caglar Turan,2 Esra Yazici2

1Department of Physiology, School of Medicine, Sakarya University, Sakarya, Turkey; 2Department of Psychiatry, School of Medicine, Sakarya University, Sakarya, Turkey

Objectives: Interactions between neuropeptides and psychiatric disorders have been investigated for many years. The aim of this study was to evaluate oxytocin (OXT), arginine-vasopressin (AVP), and atrial natriuretic peptide (ANP) and assess their interactions with each other, as well as investigate these changes with the manifestations of schizophrenia.
Participants and methods: Thirty-four individuals having acute schizophrenia and 24 healthy individuals as the control group were included in the study. Positive and Negative Syndrome Scales, Global Assessment of Functionality score, and Clinical Global Impression (CGI) scores were measured. Serum hormone levels were analyzed using enzyme-linked immunosorbent assay and were compared with the clinical findings.
Results: OXT levels were significantly lower and AVP levels were significantly higher in patients having acute schizophrenia than the control group. OXT was negatively correlated with Positive and Negative Syndrome Scales positive score and CGI score, while it was positively correlated with Global Assessment of Functionality score. AVP was negatively correlated with CGI score. ANP levels of the patients having schizophrenia were lower than the control group; however, there was no significant correlation with clinical findings.
Conclusion: The obtained data indicate that the AVP level was higher, but OXT and ANP levels were lower in the patients having acute schizophrenia. Specifically OXT is related with reduced disease severity and increased functionality.

Keywords: schizophrenia, oxytocin, PANS, GAF, CGI, AVP

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