Back to Journals » HIV/AIDS - Research and Palliative Care » Volume 2

Atherosclerosis: pathogenesis and increased occurrence in individuals with HIV and Mycobacterium tuberculosis infection

Authors Guilford T, Morris D, Gray D, Venketaraman V

Published 29 October 2010 Volume 2010:2 Pages 211—218

DOI https://doi.org/10.2147/HIV.S11977

Review by Single-blind

Peer reviewer comments 2


Timothy Guilford1, Devin Morris2,4, Dennis Gray3,4, Vishwanath Venketaraman3,4
1Your Energy Systems, Palo Alto, CA, USA; 2Graduate of College of Biomedical Sciences, 3College of Osteopathic Medicine of the Pacific, 4Western University of Health Sciences, Pomona, CA, USA

Abstract: Atherosclerosis is a leading cause of coronary heart disease and stroke. Since 1981, more than 980,000 cases of AIDS have been reported in the United States. According to the Centers for Disease Control, more than 1 million Americans may be infected with HIV. By killing or damaging CD4+ T cells of the body’s immune system, HIV progressively destroys the body’s ability to fight infections. People diagnosed with AIDS often suffer from life-threatening diseases caused by opportunistic infections such as tuberculosis. HIV-infected individuals have increased risks for atherosclerosis. This review summarizes the effects of oxidized low density lipoproteins in impairing macrophage functions in individuals with atherosclerosis (with and without HIV infection) thereby enhancing the susceptibility to Mycobacterium tuberculosis infection.

Keywords: AIDS, HIV, Mycobacterium tuberculosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]